HLA associations in clozapine-induced agranulocytosis

HLA associations in clozapine-induced agranulocytosis.

We previously reported preliminary results of association of clozapine-induced agranulocytosis (CA) with HLA-B38, DR4, DQ3 in five Ashkenazi Jewish patients and with HLA-DR2, DQ1 in four non-Jewish patients. In the present study, 31 additional patients with CA, 10 Ashkenazi Jewish, and 21 of non-Jewish ancestry, were studied. HLA alleles and haplotypes were compared among 52 patients (33 Ashken...

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer and more widespread use of clozapine. Here we perform the largest and most comprehensive genetic ...

Biological mechanisms behind clozapine-induced agranulocytosis

Agranulocytosis during Clozapine Therapy

Sir, This is in response to the article' Do Indian researchers read Indian research? a reappraisal, four years later', published in April 2000 (No.2, f Vol.42) issue of your journal. The authors of this article have documented their observations on my article 'Transsexualism in Schizophrenia : a case report' (April, 1998, Vol.40, No.2) that I did not refer to their article, 'Behaviour Therapy f...

Clozapine-induced agranulocytosis after 11 years of treatment.

http://ajp.psychiatryonline.org 2. Narendran R, Young CM, Valenti AM, Nickolova MK, Pristach CA: Is psychosis exacerbated by modafinil? (letter). Arch Gen Psychiatry 2002; 59:292–293 3. Spensley J, Rockwell DA: Psychosis during methylphenidate abuse. N Engl J Med 1972; 286:880–881 4. Leong GB, Shaner AL, Silva JA: Narcolepsy, paranoid psychosis, and analeptic abuse. Psychiatr J Univ Ott 1989; 1...